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Ha-Ras(V12)-Induced Multilayer Cellular Aggregates Is Mediated by Rac1 Activation Rather Than YAP Activation
We demonstrate that Ha-Ras(V12) overexpression induces the nuclear translocation of Hippo effector Yes-associated protein (YAP) in MDCK cells via the hippo-independent pathway at the confluent stage. Ha-Ras(V12) overexpression leads to the downregulation of Caveolin-1 (Cav1) and the disruption of ju...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138672/ https://www.ncbi.nlm.nih.gov/pubmed/35625714 http://dx.doi.org/10.3390/biomedicines10050977 |