Decoding the Role of Melatonin Structure on Plasmodium falciparum Human Malaria Parasites Synchronization Using 2-Sulfenylindoles Derivatives

Melatonin acts to synchronize the parasite’s intraerythrocytic cycle by triggering the phospholipase C-inositol 1,4,5-trisphosphate (PLC-IP(3)) signaling cascade. Compounds with an indole scaffold impair in vitro proliferation of blood-stage malaria parasites, indicating that this class of compounds...

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Detalles Bibliográficos
Autores principales: Mallaupoma, Lenna Rosanie Cordero, Dias, Bárbara Karina de Menezes, Singh, Maneesh Kumar, Honorio, Rute Isabel, Nakabashi, Myna, Kisukuri, Camila de Menezes, Paixão, Márcio Weber, Garcia, Celia R. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138683/
https://www.ncbi.nlm.nih.gov/pubmed/35625565
http://dx.doi.org/10.3390/biom12050638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138683/
https://www.ncbi.nlm.nih.gov/pubmed/35625565
http://dx.doi.org/10.3390/biom12050638

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