DYT-PRKRA Mutation P222L Enhances PACT’s Stimulatory Activity on Type I Interferon Induction

DYT-PRKRA (dystonia 16 or DYT-PRKRA) is caused by mutations in the PRKRA gene that encodes PACT, the protein activator of interferon (IFN)-induced double-stranded (ds) RNA-activated protein kinase (PKR). PACT participates in several cellular pathways, of which its role as a PKR activator protein dur...

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Detalles Bibliográficos
Autores principales: Vaughn, Lauren S., Frederick, Kenneth, Burnett, Samuel B., Sharma, Nutan, Bragg, D. Cristopher, Camargos, Sarah, Cardoso, Francisco, Patel, Rekha C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138762/
https://www.ncbi.nlm.nih.gov/pubmed/35625640
http://dx.doi.org/10.3390/biom12050713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138762/
https://www.ncbi.nlm.nih.gov/pubmed/35625640
http://dx.doi.org/10.3390/biom12050713

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