Cargando…

The Actin-Binding Protein Cortactin Promotes Sepsis Severity by Supporting Excessive Neutrophil Infiltration into the Lung

Sepsis is a systemic infection that can lead to multi-organ failure. It is characterised by an uncontrolled immune response with massive neutrophil influx into peripheral organs. Neutrophil extravasation into tissues depends on actin remodeling and actin-binding proteins such as cortactin, which is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lartey, Nathaniel L., Vargas-Robles, Hilda, Guerrero-Fonseca, Idaira M., García-Ponce, Alexander, Salinas-Lara, Citlaltepetl, Rottner, Klemens, Schnoor, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139066/ https://www.ncbi.nlm.nih.gov/pubmed/35625756 http://dx.doi.org/10.3390/biomedicines10051019

Ejemplares similares

Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility
por: García Ponce, Alexander, et al.
Publicado: (2016)

Role of Src and Cortactin in Pemphigus Skin Blistering
por: Kugelmann, Daniela, et al.
Publicado: (2019)

Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation
por: Cornelius, Jonas, et al.
Publicado: (2021)

HS1 deficiency protects against sepsis by attenuating neutrophil-inflicted lung damage
por: Guerrero-Fonseca, Idaira M., et al.
Publicado: (2022)

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo
por: Schnoor, Michael, et al.
Publicado: (2011)

Cortactin regulates the activity of small GTPases and ICAM-1 clustering in endothelium: Implications for the formation of docking structures
por: Vestweber, Dietmar, et al.
Publicado: (2013)

Helicobacter pylori CagA Induces Cortactin Y-470 Phosphorylation-Dependent Gastric Epithelial Cell Scattering via Abl, Vav2 and Rac1 Activation
por: Tegtmeyer, Nicole, et al.
Publicado: (2021)

Cortactin Is Required for Efficient FAK, Src and Abl Tyrosine Kinase Activation and Phosphorylation of Helicobacter pylori CagA
por: Knorr, Jakob, et al.
Publicado: (2021)

Abp1p and cortactin, new “hand-holds” for actin
por: Olazabal, Isabel M., et al.
Publicado: (2001)

Cortactin promotes exosome secretion by controlling branched actin dynamics
por: Sinha, Seema, et al.
Publicado: (2016)

Moesin and cortactin control actin-dependent multivesicular endosome biogenesis
por: Muriel, Olivia, et al.
Publicado: (2016)

Actin dynamics in cell migration
por: Schaks, Matthias, et al.
Publicado: (2019)

Cortactin is necessary for E-cadherin–mediated contact formation and actin reorganization
por: Helwani, Falak M., et al.
Publicado: (2004)

Releasing the brakes while hanging on: Cortactin effects on actin-driven motility
por: Gov, Nir S., et al.
Publicado: (2012)

Neutrophils Activate Tumoral CORTACTIN to Enhance Progression of Orohypopharynx Carcinoma
por: Dumitru, Claudia A., et al.
Publicado: (2013)

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation
por: Thomas, Steven G., et al.
Publicado: (2017)

High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse
por: Velázquez-Avila, Martha, et al.
Publicado: (2018)

Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-Actin and the Arp2/3 Complex
por: Weed, Scott A., et al.
Publicado: (2000)

PI(3,5)P(2) controls endosomal branched actin dynamics by regulating cortactin–actin interactions
por: Hong, Nan Hyung, et al.
Publicado: (2015)

Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells
por: Bougnères, Laurence, et al.
Publicado: (2004)

Regulated Interactions between Dynamin and the Actin-Binding Protein Cortactin Modulate Cell Shape
por: McNiven, Mark A., et al.
Publicado: (2000)

The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner
por: O'Connell, Meghan E., et al.
Publicado: (2019)

Cortactin function in invadopodia
por: Jeannot, Pauline, et al.
Publicado: (2017)

Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain
por: van Rossum, Agnes GSH, et al.
Publicado: (2005)

Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin
por: Gao, Nannan, et al.
Publicado: (2022)

Cytochalasans and Their Impact on Actin Filament Remodeling
por: Lambert, Christopher, et al.
Publicado: (2023)

Cortactin in Epithelial–Mesenchymal Transition
por: Ji, Rong, et al.
Publicado: (2020)

Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells
por: Abe, Tadashi, et al.
Publicado: (2018)

Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells
por: Abe, Tadashi, et al.
Publicado: (2020)

Cortactin Is Involved in the Entry of Coxiella burnetii into Non-Phagocytic Cells
por: Rosales, Eliana M., et al.
Publicado: (2012)

F- and G-Actin Concentrations in Lamellipodia of Moving Cells
por: Koestler, Stefan A., et al.
Publicado: (2009)

Cortactin Phosphorylated by ERK1/2 Localizes to Sites of Dynamic Actin Regulation and Is Required for Carcinoma Lamellipodia Persistence
por: Kelley, Laura C., et al.
Publicado: (2010)

An Actin-, Cortactin- and Ena-VASP-Linked Complex Contributes to Endothelial Cell Focal Adhesion and Vascular Barrier Regulation
por: Mascarenhas, Joseph B., et al.
Publicado: (2022)

Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly
por: Dimchev, Georgi, et al.
Publicado: (2017)

Cortactin and phagocytosis in isolated Sertoli cells
por: Wolski, Katja M, et al.
Publicado: (2005)

Cortactin in cancer cell migration and invasion
por: Yin, Miao, et al.
Publicado: (2017)

Cortactin in Lung Cell Function and Disease
por: Bandela, Mounica, et al.
Publicado: (2022)

PLCβ3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration
por: Janjanam, Jagadeesh, et al.
Publicado: (2015)

The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 Domain
por: González-Jamett, Arlek M., et al.
Publicado: (2017)

Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice
por: van Rossum, Agnes GSH, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_4a57d3l509amgefv9e0rqft354