Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking

SIMPLE SUMMARY: Extracellular vesicles shed from primary cilia may be involved in renal cystogenesis. The disruption of the Pkd1 gene in our cell culture system increased the production of EVs in a similar way that occurs when the Tsc2 gene is disrupted. Disruption of the primary cilia depresses EV...

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Detalles Bibliográficos
Autores principales: Kumar, Prashant, Zadjali, Fahad, Yao, Ying, Köttgen, Michael, Hofherr, Alexis, Gross, Kenneth W., Mehta, Darshan, Bissler, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139108/
https://www.ncbi.nlm.nih.gov/pubmed/35625437
http://dx.doi.org/10.3390/biology11050709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139108/
https://www.ncbi.nlm.nih.gov/pubmed/35625437
http://dx.doi.org/10.3390/biology11050709

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