Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin–Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, the fundamental unit of cardiac muscle. Diabetes mellitus (DM) can cause desmin to become dysregulated, following episodes of nitrosative stress, through the activation of the iNOS/mTOR/TIMP...

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Detalles Bibliográficos
Autores principales: Dawood, Amal F., Alzamil, Norah M., Hewett, Peter W., Momenah, Maha A., Dallak, Mohammad, Kamar, Samaa S., Abdel Kader, Dina H., Yassin, Hanaa, Haidara, Mohamed A., Maarouf, Amro, Al-Ani, Bahjat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139128/
https://www.ncbi.nlm.nih.gov/pubmed/35625721
http://dx.doi.org/10.3390/biomedicines10050984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139128/
https://www.ncbi.nlm.nih.gov/pubmed/35625721
http://dx.doi.org/10.3390/biomedicines10050984

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