Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer

SIMPLE SUMMARY: Recent studies re-classified the c.5339T->C; p.Leu1780Pro (L1780P) BRCA1 missense mutation as “likely pathogenic” in ACMG classification, which shows a high prevalence in the Korean population. This study aims to reveal the molecular mechanisms and therapeutic relevance of BRCA1 L...

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Detalles Bibliográficos
Autores principales: Lee, Jeong Dong, Ryu, Won-Ji, Han, Hyun Ju, Kim, Tae Yeong, Kim, Min Hwan, Sohn, Joohyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139203/
https://www.ncbi.nlm.nih.gov/pubmed/35626017
http://dx.doi.org/10.3390/cancers14102405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139203/
https://www.ncbi.nlm.nih.gov/pubmed/35626017
http://dx.doi.org/10.3390/cancers14102405

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