Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia

The transcription factor hypoxia-inducible factor (HIF) is the main oxygen sensor which regulates adaptation to cellular hypoxia. The aim of this study was to establish cultured murine hepatocyte derived cells (mHDC) as an in vitro model and to analyze the role of HIF-1α in apoptosis induction, DNA...

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Detalles Bibliográficos
Autores principales: Hamidi, Akram, Wolf, Alexandra, Dueva, Rositsa, Kaufmann, Melanie, Göpelt, Kirsten, Iliakis, George, Metzen, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139307/
https://www.ncbi.nlm.nih.gov/pubmed/35626708
http://dx.doi.org/10.3390/cells11101671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139307/
https://www.ncbi.nlm.nih.gov/pubmed/35626708
http://dx.doi.org/10.3390/cells11101671

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