Cargando…

Distinct Effector Programs of Brain-Homing CD8(+) T Cells in Multiple Sclerosis

The effector programs of CD8(+) memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8(+) memory T cells in multiple sclerosis (MS) remains unknown. To address this, we analyzed blood, CSF and brain tissues from MS patients for th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koetzier, Steven C., van Langelaar, Jamie, Melief, Marie-José, Wierenga-Wolf, Annet F., Corsten, Cato E. A., Blok, Katelijn M., Hoeks, Cindy, Broux, Bieke, Wokke, Beatrijs, van Luijn, Marvin M., Smolders, Joost
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139595/ https://www.ncbi.nlm.nih.gov/pubmed/35626671 http://dx.doi.org/10.3390/cells11101634

Ejemplares similares

Naive B cells in neuromyelitis optica spectrum disorders: impact of steroid use and relapses
por: Janssen, Malou, et al.
Publicado: (2020)

Improving Glucocorticoid Sensitivity of Brain-Homing CD4(+) T Helper Cells by Steroid Hormone Crosstalk
por: Koetzier, Steven C., et al.
Publicado: (2022)

Effector T Helper Cells Are Selectively Controlled During Pregnancy and Related to a Postpartum Relapse in Multiple Sclerosis
por: Koetzier, Steven C., et al.
Publicado: (2021)

Human T-bet(+) B cell development is associated with BTK activity and suppressed by evobrutinib
por: Rijvers, Liza, et al.
Publicado: (2022)

Brain-homing CD4(+) T cells display glucocorticoid-resistant features in MS
por: Koetzier, Steven C., et al.
Publicado: (2020)

Pregnancy-induced effects on memory B-cell development in multiple sclerosis
por: Janssen, Malou, et al.
Publicado: (2021)

Disease activity in primary progressive multiple sclerosis: a systematic review and meta-analysis
por: Blok, Katelijn M., et al.
Publicado: (2023)

Health-economic benefits of anti-CD20 treatments in relapsing multiple sclerosis estimated using a treatment-sequence model
por: Smets, Ide, et al.
Publicado: (2023)

Pediatric MS patients with a primary progressive-like disease may still have relevant inflammatory activity and may benefit from regular MS treatment
por: Bruijstens, Arlette L, et al.
Publicado: (2020)

B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers
por: van Langelaar, Jamie, et al.
Publicado: (2020)

Selective emergence of antibody-secreting cells in the multiple sclerosis brain
por: Bogers, Laurens, et al.
Publicado: (2023)

The association of Epstein‐Barr virus infection with CXCR3(+) B‐cell development in multiple sclerosis: impact of immunotherapies
por: van Langelaar, Jamie, et al.
Publicado: (2020)

Should anti-CD20 be used as an immune reconstitution therapy?
por: Smets, Ide, et al.
Publicado: (2022)

Induction of brain‐infiltrating T‐bet–expressing B cells in multiple sclerosis
por: van Langelaar, Jamie, et al.
Publicado: (2019)

When Helpers Go Above and Beyond: Development and Characterization of Cytotoxic CD4(+) T Cells
por: Hoeks, Cindy, et al.
Publicado: (2022)

The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis
por: Rijvers, Liza, et al.
Publicado: (2018)

Nectin Family Ligands Trigger Immune Effector Functions in Health and Autoimmunity
por: Hermans, Doryssa, et al.
Publicado: (2023)

T-cell surveillance of the human brain in health and multiple sclerosis
por: Smolders, Joost, et al.
Publicado: (2022)

Treg-Resistant Cytotoxic CD4(+) T Cells Dictate T Helper Cells in Their Vicinity: TH17 Skewing and Modulation of Proliferation
por: Hoeks, Cindy, et al.
Publicado: (2021)

L-Arginine Depletion Improves Spinal Cord Injury via Immunomodulation and Nitric Oxide Reduction
por: Erens, Céline, et al.
Publicado: (2022)

High neurofilament levels are associated with clinically definite multiple sclerosis in children and adults with clinically isolated syndrome
por: van der Vuurst de Vries, Roos M, et al.
Publicado: (2018)

Editorial: Neuro-Immune Connections to Enable Repair in CNS Disorders
por: Vanmierlo, Tim, et al.
Publicado: (2020)

Oncostatin M, an Underestimated Player in the Central Nervous System
por: Houben, Evelien, et al.
Publicado: (2019)

Regulatory T cell therapy for multiple sclerosis: Breaching (blood-brain) barriers
por: Verreycken, Janne, et al.
Publicado: (2022)

Improving the Efficacy of Regulatory T Cell Therapy
por: Baeten, Paulien, et al.
Publicado: (2021)

Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis
por: Brockington, Alice, et al.
Publicado: (2007)

Multiple sclerosis risk variants influence the peripheral B‐cell compartment early in life in the general population
por: de Mol, Casper L., et al.
Publicado: (2022)

Abundant kif21b is associated with accelerated progression in neurodegenerative diseases
por: Kreft, Karim L, et al.
Publicado: (2014)

Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis
por: Sadeghi Hassanabadi, Negar, et al.
Publicado: (2022)

Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression
por: Peeters, Liesbet M., et al.
Publicado: (2017)

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients
por: van Nierop, Gijsbert P., et al.
Publicado: (2017)

CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis
por: Bogie, Jeroen FJ, et al.
Publicado: (2020)

T cell composition and polygenic multiple sclerosis risk: A population‐based study in children
por: de Mol, Casper L., et al.
Publicado: (2021)

Compositional Changes of B and T Cell Subtypes during Fingolimod Treatment in Multiple Sclerosis Patients: A 12-Month Follow-Up Study
por: Claes, Nele, et al.
Publicado: (2014)

T-cell activation marker sCD27 is associated with clinically definite multiple sclerosis in childhood-acquired demyelinating syndromes
por: Wong, Yu Yi M, et al.
Publicado: (2018)

Smoking at time of CIS increases the risk of clinically definite multiple sclerosis
por: van der Vuurst de Vries, Roos M., et al.
Publicado: (2018)

Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation
por: van Luijn, Marvin M., et al.
Publicado: (2012)

Spinal Cord Ischemia Related to Disc Herniation: Case Report and a Review of the Literature
por: Aalbers, Marlien W, et al.
Publicado: (2021)

Vitamin D and Multiple Sclerosis: Correlation, Causality, and Controversy
por: Smolders, Joost
Publicado: (2010)

Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation
por: Vanheusden, Marjan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dpdhe6je2nbbd2amebmiu335d7