ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

The extracellular aggregation of destabilized transthyretin (TTR) variants is implicated in the onset and pathogenesis of familial TTR-related amyloid diseases. One strategy to reduce the toxic, extracellular aggregation of TTR is to decrease the population of aggregation-prone proteins secreted fro...

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Detalles Bibliográficos
Autores principales: Mesgarzadeh, Jaleh S., Romine, Isabelle C., Smith-Cohen, Ethan M., Grandjean, Julia M. D., Kelly, Jeffery W., Genereux, Joseph C., Wiseman, R. Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139617/
https://www.ncbi.nlm.nih.gov/pubmed/35626697
http://dx.doi.org/10.3390/cells11101661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139617/
https://www.ncbi.nlm.nih.gov/pubmed/35626697
http://dx.doi.org/10.3390/cells11101661

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