Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons

To model α-Synuclein (αS) aggregation and neurodegeneration in Parkinson’s disease (PD), we established cultures of mouse midbrain dopamine (DA) neurons and chronically exposed them to fibrils 91 (F91) generated from recombinant human αS. We found that F91 have an exquisite propensity to seed the ag...

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Detalles Bibliográficos
Autores principales: Tourville, Aurore, Akbar, David, Corti, Olga, Prehn, Jochen H. M., Melki, Ronald, Hunot, Stéphane, Michel, Patrick P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139621/
https://www.ncbi.nlm.nih.gov/pubmed/35626675
http://dx.doi.org/10.3390/cells11101640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139621/
https://www.ncbi.nlm.nih.gov/pubmed/35626675
http://dx.doi.org/10.3390/cells11101640

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