p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation

SIMPLE SUMMARY: Chronic liver injury is a predisposing factor for hepatocellular carcinoma (HCC) development. p62-mediated Nrf2 overactivation has been shown to drive liver injury and HCC in mice with hepatic impairment of autophagy. Here, we addressed the role of this pathway in a liver disease mou...

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Autores principales: Kondylis, Vangelis, Schneider, Farina, Schorn, Fabian, Oikonomou, Nikos, Straub, Beate Katharina, Werner, Sabine, Rosenstiel, Philip, Pasparakis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139637/
https://www.ncbi.nlm.nih.gov/pubmed/35626041
http://dx.doi.org/10.3390/cancers14102436

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