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Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke

Heat stroke (HS) is a severe condition characterized by increased morbidity and high mortality. Acute liver injury (ALI) is a well-documented complication of HS. The tumor suppressor p53 plays an important role in regulation of mitochondrial integrity and mitophagy in several forms of ALI. However,...

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Detalles Bibliográficos
Autores principales: Huang, Wei, Xie, Weidang, Zhong, Hanhui, Cai, Shumin, Huang, Qiaobing, Liu, Youtan, Zeng, Zhenhua, Liu, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139682/
https://www.ncbi.nlm.nih.gov/pubmed/35634298
http://dx.doi.org/10.3389/fimmu.2022.859231