Cytoplasmic Clusterin Suppresses Lung Cancer Metastasis by Inhibiting the ROCK1-ERK Axis

SIMPLE SUMMARY: We show that CLU, especially cytoplasmic precursor CLU, is downregulated in lung cancer and correlates with poor survival. The silencing of CLU promotes lung cancer cell migration and invasion, while the overexpression of CLU potently inhibits these phenomena. Interestingly, secretor...

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Detalles Bibliográficos
Autores principales: Huang, Shaobo, Li, Xu, Gu, Weiqi, Li, Xiaoyi, Zhao, Jingjing, Wu, Jueheng, Cai, Junchao, Feng, Xianming, Tao, Tianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140019/
https://www.ncbi.nlm.nih.gov/pubmed/35626071
http://dx.doi.org/10.3390/cancers14102463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140019/
https://www.ncbi.nlm.nih.gov/pubmed/35626071
http://dx.doi.org/10.3390/cancers14102463

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