Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System

HepG2 cells are an inexpensive hepatocyte model that can be used for repeated experiments, but HepG2 cells do not express major cytochrome P450s (CYPs) and UDP glucuronosyltransferase family 1 member A1 (UGT1A1). In this study, we established CYP3A4–POR–UGT1A1–CYP1A2–CYP2C19–CYP2C9–CYP2D6 (CYPs–UGT1...

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Detalles Bibliográficos
Autores principales: Negoro, Ryosuke, Tasaka, Mitsuki, Deguchi, Sayaka, Takayama, Kazuo, Fujita, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140068/
https://www.ncbi.nlm.nih.gov/pubmed/35626714
http://dx.doi.org/10.3390/cells11101677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140068/
https://www.ncbi.nlm.nih.gov/pubmed/35626714
http://dx.doi.org/10.3390/cells11101677

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