Distinct structural groups of histone H3 and H4 residues have divergent effects on chronological lifespan in Saccharomyces cerevisiae

We have performed a comprehensive analysis of the involvement of histone H3 and H4 residues in the regulation of chronological lifespan in yeast and identify four structural groups in the nucleosome that influence lifespan. We also identify residues where substitution with an epigenetic mimic extend...

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Detalles Bibliográficos
Autores principales: Ngubo, Mzwanele, Reid, Jessica Laura, Patterton, Hugh–George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140238/
https://www.ncbi.nlm.nih.gov/pubmed/35622816
http://dx.doi.org/10.1371/journal.pone.0268760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140238/
https://www.ncbi.nlm.nih.gov/pubmed/35622816
http://dx.doi.org/10.1371/journal.pone.0268760

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