Evolution of tunnels in α/β-hydrolase fold proteins—What can we learn from studying epoxide hydrolases?

The evolutionary variability of a protein’s residues is highly dependent on protein region and function. Solvent-exposed residues, excluding those at interaction interfaces, are more variable than buried residues whereas active site residues are considered to be conserved. The abovementioned rules a...

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Detalles Bibliográficos
Autores principales: Bzówka, Maria, Mitusińska, Karolina, Raczyńska, Agata, Skalski, Tomasz, Samol, Aleksandra, Bagrowska, Weronika, Magdziarz, Tomasz, Góra, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140254/
https://www.ncbi.nlm.nih.gov/pubmed/35580137
http://dx.doi.org/10.1371/journal.pcbi.1010119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140254/
https://www.ncbi.nlm.nih.gov/pubmed/35580137
http://dx.doi.org/10.1371/journal.pcbi.1010119

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