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Evolution of tunnels in α/β-hydrolase fold proteins—What can we learn from studying epoxide hydrolases?
The evolutionary variability of a protein’s residues is highly dependent on protein region and function. Solvent-exposed residues, excluding those at interaction interfaces, are more variable than buried residues whereas active site residues are considered to be conserved. The abovementioned rules a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140254/ https://www.ncbi.nlm.nih.gov/pubmed/35580137 http://dx.doi.org/10.1371/journal.pcbi.1010119 |