Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling

Elevated levels of Mucin-16 (MUC16) in conjunction with a high expression of truncated O-glycans is implicated in playing crucial roles in the malignancy of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms by which such aberrant glycoforms present on MUC16 itself promote an increased...

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Detalles Bibliográficos
Autores principales: Rajesh, Christabelle, Sagar, Satish, Rathinavel, Ashok Kumar, Chemparathy, Divya Thomas, Peng, Xianlu Laura, Yeh, Jen Jen, Hollingsworth, Michael A., Radhakrishnan, Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141077/
https://www.ncbi.nlm.nih.gov/pubmed/35628269
http://dx.doi.org/10.3390/ijms23105459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141077/
https://www.ncbi.nlm.nih.gov/pubmed/35628269
http://dx.doi.org/10.3390/ijms23105459

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