miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin

Megakaryocytes release submicron size microparticles (MkMPs) in circulation. We have shown that MkMPs target CD34+ hematopoietic stem/progenitor cells (HSPCs) to induce megakaryocytic differentiation, and that small RNAs in MkMPs play an important role in the development of this phenotype. Here, usi...

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Detalles Bibliográficos
Autores principales: Kao, Chen-Yuan, Jiang, Jinlin, Thompson, Will, Papoutsakis, Eleftherios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141330/
https://www.ncbi.nlm.nih.gov/pubmed/35628168
http://dx.doi.org/10.3390/ijms23105355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141330/
https://www.ncbi.nlm.nih.gov/pubmed/35628168
http://dx.doi.org/10.3390/ijms23105355

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