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miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin
Megakaryocytes release submicron size microparticles (MkMPs) in circulation. We have shown that MkMPs target CD34+ hematopoietic stem/progenitor cells (HSPCs) to induce megakaryocytic differentiation, and that small RNAs in MkMPs play an important role in the development of this phenotype. Here, usi...
Autores principales: | Kao, Chen-Yuan, Jiang, Jinlin, Thompson, Will, Papoutsakis, Eleftherios T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141330/ https://www.ncbi.nlm.nih.gov/pubmed/35628168 http://dx.doi.org/10.3390/ijms23105355 |
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