p53N236S Activates Autophagy in Response to Hypoxic Stress Induced by DFO

Hypoxia can lead to stabilization of the tumor suppressor gene p53 and cell death. However, p53 mutations could promote cell survival in a hypoxic environment. In this study, we found that p53N236S (p53N239S in humans, hereinafter referred to as p53S) mutant mouse embryonic fibroblasts (MEFs) resist...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Kang, Zong, Huanhuan, Hou, Kailong, Zhang, Yanduo, Zhang, Ruyi, Zhao, Dan, Guo, Xin, Luo, Ying, Jia, Shuting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141750/
https://www.ncbi.nlm.nih.gov/pubmed/35627147
http://dx.doi.org/10.3390/genes13050763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141750/
https://www.ncbi.nlm.nih.gov/pubmed/35627147
http://dx.doi.org/10.3390/genes13050763

Ejemplares similares