Hyaluronidase Enhances Targeting of Hydrogel-Encapsulated Anti-CTLA-4 to Tumor Draining Lymph Nodes and Improves Anti-Tumor Efficacy

Immunotherapy targeting checkpoint inhibitors, such as CTLA-4 and/or PD-1, has emerged as a leading cancer therapy. While their combination produces superior efficacy compared to monotherapy, it also magnifies inflammatory and autoimmune toxicity that limits clinical utility. We previously reported...

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Detalles Bibliográficos
Autores principales: Harui, Airi, Roth, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141760/
https://www.ncbi.nlm.nih.gov/pubmed/35621582
http://dx.doi.org/10.3390/gels8050284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141760/
https://www.ncbi.nlm.nih.gov/pubmed/35621582
http://dx.doi.org/10.3390/gels8050284

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