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Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans
Distinguishing between conserved and divergent regulatory mechanisms is essential for translating preclinical research from mice to humans, yet there is a lack of information about how evolutionary genome rearrangements affect the regulation of the immune response, a rapidly evolving system. The cur...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142060/ https://www.ncbi.nlm.nih.gov/pubmed/35508135 http://dx.doi.org/10.1016/j.celrep.2022.110769 |