Double-Stranded Break Repair in Mammalian Cells and Precise Genome Editing

In mammalian cells, double-strand breaks (DSBs) are repaired predominantly by error-prone non-homologous end joining (NHEJ), but less prevalently by error-free template-dependent homologous recombination (HR). DSB repair pathway selection is the bedrock for genome editing. NHEJ results in random mut...

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Detalles Bibliográficos
Autores principales: Ali, Akhtar, Xiao, Wei, Babar, Masroor Ellahi, Bi, Yanzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142082/
https://www.ncbi.nlm.nih.gov/pubmed/35627122
http://dx.doi.org/10.3390/genes13050737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142082/
https://www.ncbi.nlm.nih.gov/pubmed/35627122
http://dx.doi.org/10.3390/genes13050737

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