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Concurrent Akt, ERK1/2 and AMPK Activation by Obestatin Inhibits Apoptotic Signaling Cascades on Nutrient-Deprived PC12 Cells

Targeting apoptosis in the ischemic penumbra is a rational therapeutic approach for restricting cerebral infarct volume after clinical stroke. The present work explored the capability of the obestatin peptide, as a novel approach to inhibit apoptotic signaling cascades on PC12 cells. According to th...

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Detalles Bibliográficos
Autores principales: Sánchez-Temprano, Agustín, Relova, José Luis, Camiña, Jesús P., Pazos, Yolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142446/
https://www.ncbi.nlm.nih.gov/pubmed/33400083
http://dx.doi.org/10.1007/s10571-020-01025-8