FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine

Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly characterized by extreme hypersensitivity to interstrand crosslink (ICL) agents. Additionally, the FA proteins play a crucial role in concert with homologous recombination (HR) fac...

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Detalles Bibliográficos
Autores principales: Peña-Gómez, María José, Moreno-Gordillo, Paula, Narmontė, Milda, García-Calderón, Clara B., Rukšėnaitė, Audronė, Klimašauskas, Saulius, Rosado, Iván V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142498/
https://www.ncbi.nlm.nih.gov/pubmed/35624090
http://dx.doi.org/10.1038/s41419-022-04952-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142498/
https://www.ncbi.nlm.nih.gov/pubmed/35624090
http://dx.doi.org/10.1038/s41419-022-04952-0

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