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Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles

Alzheimer’s disease (AD) is defined by intracellular neurofibrillary tangles formed by the microtubule-associated protein tau and extracellular plaques formed by the β-amyloid peptide. AD tau tangles contain a mixture of tau isoforms with either four (4R) or three (3R) microtubule-binding repeats. H...

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Detalles Bibliográficos
Autores principales: Dregni, Aurelio J., Duan, Pu, Xu, Hong, Changolkar, Lakshmi, El Mammeri, Nadia, Lee, Virginia M.-Y., Hong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142584/
https://www.ncbi.nlm.nih.gov/pubmed/35624093
http://dx.doi.org/10.1038/s41467-022-30585-0