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Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery

Compared with siRNAs or other antisense oligonucleotides (ASOs), the chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability of threose nucleic acid (TNA) motivate scientists to explore it as a novel molecular tool in biomedical a...

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Detalles Bibliográficos
Autores principales: Wang, Fei, Liu, Ling Sum, Li, Pan, Lau, Cia Hin, Leung, Hoi Man, Chin, Y Rebecca, Tin, Chung, Lo, Pik Kwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142632/
https://www.ncbi.nlm.nih.gov/pubmed/35637854
http://dx.doi.org/10.1016/j.mtbio.2022.100299