Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death

Sirtuin-1 (SIRT1) is a critical nuclear deacetylase that participates in a wide range of biological processes. We hereby employed quantitative acetyl-proteomics to globally reveal the landscape of SIRT1-dependent acetylation in colorectal cancer (CRC) cells stimulated by specific SIRT1 inhibitor Ina...

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Detalles Bibliográficos
Autores principales: Sun, Yue, Yang, Yan-Ming, Hu, Yu-Yu, Ouyang, Lan, Sun, Zheng-Hua, Yin, Xing-Feng, Li, Nan, He, Qing-Yu, Wang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142701/
https://www.ncbi.nlm.nih.gov/pubmed/35636016
http://dx.doi.org/10.1016/j.redox.2022.102334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142701/
https://www.ncbi.nlm.nih.gov/pubmed/35636016
http://dx.doi.org/10.1016/j.redox.2022.102334

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