Cargando…

Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death

Sirtuin-1 (SIRT1) is a critical nuclear deacetylase that participates in a wide range of biological processes. We hereby employed quantitative acetyl-proteomics to globally reveal the landscape of SIRT1-dependent acetylation in colorectal cancer (CRC) cells stimulated by specific SIRT1 inhibitor Ina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Yue, Yang, Yan-Ming, Hu, Yu-Yu, Ouyang, Lan, Sun, Zheng-Hua, Yin, Xing-Feng, Li, Nan, He, Qing-Yu, Wang, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142701/ https://www.ncbi.nlm.nih.gov/pubmed/35636016 http://dx.doi.org/10.1016/j.redox.2022.102334

Ejemplares similares

Calcium Overload and Mitochondrial Metabolism
por: Walkon, Lauren L., et al.
Publicado: (2022)

Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1
por: Siegel, David, et al.
Publicado: (2022)

Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model
por: Zeng, Lingling, et al.
Publicado: (2014)

Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis
por: Zhang, Yu, et al.
Publicado: (2021)

Sirtuin deacetylases in neurodegenerative diseases of aging
por: Herskovits, Adrianna Z, et al.
Publicado: (2013)

Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation
por: Workman, Jason J., et al.
Publicado: (2016)

Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins
por: Eldridge, Matthew J. G., et al.
Publicado: (2020)

Sirtuin Deacetylases as Therapeutic Targets in the Nervous System
por: Langley, Brett, et al.
Publicado: (2013)

Mitochondrial sirtuin 3 and various cell death modalities
por: Yapryntseva, Maria A., et al.
Publicado: (2022)

Modeling the Effects of Calcium Overload on Mitochondrial Ultrastructural Remodeling
por: Strubbe-Rivera, Jasiel O., et al.
Publicado: (2021)

Sirtuins: Sir2-related NAD-dependent protein deacetylases
por: North, Brian J, et al.
Publicado: (2004)

Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins
por: Dai, Yan, et al.
Publicado: (2008)

Genetic Analysis of Sirtuin Deacetylases in Hyphal Growth of Candida albicans
por: Zhao, Guolei, et al.
Publicado: (2021)

Acetylation and Histone Deacetylase Inhibitors in Cancer
por: Kortenhorst, Madeleine S. Q., et al.
Publicado: (2006)

Histone deacetylases control lysine acetylation of ribosomal proteins in rice
por: Xu, Qiutao, et al.
Publicado: (2021)

Proteomic Investigations of Lysine Acetylation Identify Diverse Substrates of Mitochondrial Deacetylase Sirt3
por: Sol, Eri Maria, et al.
Publicado: (2012)

Mitochondrial Sirtuins in Reproduction
por: Di Emidio, Giovanna, et al.
Publicado: (2021)

The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection
por: Sheng, Xinlei, et al.
Publicado: (2021)

A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase
por: VanDrisse, Chelsey M., et al.
Publicado: (2017)

The Flavoring Agent Dihydrocoumarin Reverses Epigenetic Silencing and Inhibits Sirtuin Deacetylases
por: Olaharski, Andrew J, et al.
Publicado: (2005)

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity
por: Finley, Lydia W. S., et al.
Publicado: (2011)

The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload
por: Charles, Emilie, et al.
Publicado: (2016)

Myelodysplastic Syndrome and Histone Deacetylase Inhibitors: “To Be or Not to Be Acetylated”?
por: Stintzing, Sebastian, et al.
Publicado: (2011)

The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes
por: Langsfeld, Erika S., et al.
Publicado: (2015)

Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway
por: Tian, Qing, et al.
Publicado: (2016)

SERPINA3K Prevents Oxidative Stress Induced Necrotic Cell Death by Inhibiting Calcium Overload
por: Zhang, Bin, et al.
Publicado: (2008)

Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission
por: Liang, Xiao-Ling, et al.
Publicado: (2023)

Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis
por: Hwang, Young-Ji, et al.
Publicado: (2020)

Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
por: Yang, Penghua, et al.
Publicado: (2019)

Nuclear Sirtuins and the Aging of the Immune System
por: Gámez-García, Andrés, et al.
Publicado: (2021)

Oxidative stress induces mitochondrial iron overload and ferroptotic cell death
por: Chen, Yi, et al.
Publicado: (2023)

Histone deacetylase 3 indirectly modulates tubulin acetylation
por: Bacon, Travis, et al.
Publicado: (2015)

Lead Poisoning Disturbs Oligodendrocytes Differentiation Involved in Decreased Expression of NCX3 Inducing Intracellular Calcium Overload
por: Ma, Teng, et al.
Publicado: (2015)

Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload
por: Ge, Chentao, et al.
Publicado: (2019)

Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24-mediated nuclear membrane instability
por: Kong, Keyu, et al.
Publicado: (2023)

Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway
por: Lan, Xintian, et al.
Publicado: (2023)

Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases
por: McConnell, Melanie J., et al.
Publicado: (2015)

An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity
por: Roche, Kathryn L., et al.
Publicado: (2023)

Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells
por: Yoon, Kyoung B., et al.
Publicado: (2016)

Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine
por: Wongjaikam, Suwakon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gbcv0b9dc22cpglq9n2stl61om