Carbonic Anhydrase IX-Targeted α-Radionuclide Therapy with 225Ac Inhibits Tumor Growth in a Renal Cell Carcinoma Model

In this study, we compared the tumor-targeting properties, therapeutic efficacy, and tolerability of the humanized anti-CAIX antibody (hG250) labeled with either the α-emitter actinium-225 ((225)Ac) or the β(-)-emitter lutetium-177 ((177)Lu) in mice. BALB/c nude mice were grafted with human renal ce...

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Detalles Bibliográficos
Autores principales: Merkx, Robin I. J., Rijpkema, Mark, Franssen, Gerben M., Kip, Annemarie, Smeets, Bart, Morgenstern, Alfred, Bruchertseifer, Frank, Yan, Eddie, Wheatcroft, Michael P., Oosterwijk, Egbert, Mulders, Peter F. A., Heskamp, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142961/
https://www.ncbi.nlm.nih.gov/pubmed/35631396
http://dx.doi.org/10.3390/ph15050570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142961/
https://www.ncbi.nlm.nih.gov/pubmed/35631396
http://dx.doi.org/10.3390/ph15050570

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