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Synthesis and Biological Evaluation of 5′-O-Fatty Acyl Ester Derivatives of 3′-Fluoro-2′,3′-dideoxythymidine as Potential Anti-HIV Microbicides

A number of 5′-O-fatty acyl derivatives of 3′-fluoro-2′,3′-dideoxythymidine (FLT, 1) were synthesized. These conjugates were evaluated for their potential as topical microbicides with anti-HIV activity against cell-free (X4 and R5), cell-associated, and multidrug-resistant viruses. Compared to FLT a...

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Detalles Bibliográficos
Autores principales: Agarwal, Hitesh K., Chhikara, Bhupender S., Ye, Guofeng, Bhavaraju, Sitaram, Dixit, Ajay, Kumar, Anil, Doncel, Gustavo F., Parang, Keykavous
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143043/
https://www.ncbi.nlm.nih.gov/pubmed/35630829
http://dx.doi.org/10.3390/molecules27103352