Common UGT1A6 Variant Alleles Determine Acetaminophen Pharmacokinetics in Man

Acetaminophen (paracetamol) is a widely used drug that causes adverse drug events that are often dose-dependent and related to plasma drug concentrations. Acetaminophen metabolism strongly depends on UGT1A enzymes. We aimed to investigate putative factors influencing acetaminophen pharmacokinetics....

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Detalles Bibliográficos
Autores principales: Cerezo-Arias, María de las Olas, Gómez-Tabales, Javier, Martí, Manuel, García-Martín, Elena, Agúndez, José A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143054/
https://www.ncbi.nlm.nih.gov/pubmed/35629143
http://dx.doi.org/10.3390/jpm12050720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143054/
https://www.ncbi.nlm.nih.gov/pubmed/35629143
http://dx.doi.org/10.3390/jpm12050720

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