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Covalent Inhibition of the Human 20S Proteasome with Homobelactosin C Inquired by QM/MM Studies
20S proteasome is a main player in the protein degradation pathway in the cytosol, thus intervening in multiple pivotal cellular processes. Over the years the proteasome has emerged as a crucial target for the treatment of many diseases such as neurodegenerative diseases, cancer, autoimmune diseases...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143130/ https://www.ncbi.nlm.nih.gov/pubmed/35631358 http://dx.doi.org/10.3390/ph15050531 |