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Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study

Background: Currently, following the new advances in cancer treatments and the increasing prevalence of kidney disease in the population, more kidney biopsies are being performed. The aim of our study is to analyze clinical and histological characteristics of patients with active solid organ maligna...

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Autores principales: Bolufer, Mónica, García-Carro, Clara, Blasco, Miquel, Quintana, Luis F., Shabaka, Amir, Rabasco, Cristina, Draibe, Juliana, Merino, Ana, Melero, María Rosa, Alonso, Fabiola, Buxeda, Anna, Batalha, Paula, Visús, Maria Teresa, Soler, Maria José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143132/
https://www.ncbi.nlm.nih.gov/pubmed/35629041
http://dx.doi.org/10.3390/jcm11102915
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author Bolufer, Mónica
García-Carro, Clara
Blasco, Miquel
Quintana, Luis F.
Shabaka, Amir
Rabasco, Cristina
Draibe, Juliana
Merino, Ana
Melero, María Rosa
Alonso, Fabiola
Buxeda, Anna
Batalha, Paula
Visús, Maria Teresa
Soler, Maria José
author_facet Bolufer, Mónica
García-Carro, Clara
Blasco, Miquel
Quintana, Luis F.
Shabaka, Amir
Rabasco, Cristina
Draibe, Juliana
Merino, Ana
Melero, María Rosa
Alonso, Fabiola
Buxeda, Anna
Batalha, Paula
Visús, Maria Teresa
Soler, Maria José
author_sort Bolufer, Mónica
collection PubMed
description Background: Currently, following the new advances in cancer treatments and the increasing prevalence of kidney disease in the population, more kidney biopsies are being performed. The aim of our study is to analyze clinical and histological characteristics of patients with active solid organ malignancy who underwent kidney biopsy. This is a multi-center collaborative retrospective study supported by groups GLOSEN/Onconephrology from the Spanish Society of Nephrology. Clinical, demographical and histological data were collected. Results: A total of 148 patients with cancer who underwent a kidney biopsy from 12 hospitals were included. 64.3% men and mean age of 66.9 years old. The indications for biopsy were acute renal injury (67.1%), proteinuria (17.1%), exacerbated chronic kidney disease (8.2%), and chronic kidney disease (7.5%). Most frequent malignances were lung (29.1%) and abdominal (25%), with 49.7% metastatic cancer. As oncospecific treatment, 28% received chemotherapy, 29.3% immunotherapy, 19.3% specific therapies, and 2.1% conservative treatment. At the time of kidney biopsy, median creatinine was of 2.58 mg/dL [1.81–4.1 (IQ 25–75)], median urine protein-to-creatinine ratio of 700 mg/g [256–2463 (IQ 25–75)] and 53.1% presented hematuria. The most frequent renal biopsy diagnoses were: acute interstitial nephritis (39.9%), acute tubular necrosis (8.8%), IgA nephropathy (7.4%) and membranous nephropathy (6.1%). Median follow-up was 15.2 months [5.7–31.4 (IQ 25–75)]. Conclusions: There is a new trend in kidney disease and cancer patients in terms of diagnosis and treatment. Acute interstitial nephritis has established itself as the most common kidney injury in patients with cancer who underwent a kidney biopsy. Renal biopsy is a valuable tool for diagnosis, treatment, and prognosis of solid organ cancer patients with kidney damage.
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spelling pubmed-91431322022-05-29 Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study Bolufer, Mónica García-Carro, Clara Blasco, Miquel Quintana, Luis F. Shabaka, Amir Rabasco, Cristina Draibe, Juliana Merino, Ana Melero, María Rosa Alonso, Fabiola Buxeda, Anna Batalha, Paula Visús, Maria Teresa Soler, Maria José J Clin Med Article Background: Currently, following the new advances in cancer treatments and the increasing prevalence of kidney disease in the population, more kidney biopsies are being performed. The aim of our study is to analyze clinical and histological characteristics of patients with active solid organ malignancy who underwent kidney biopsy. This is a multi-center collaborative retrospective study supported by groups GLOSEN/Onconephrology from the Spanish Society of Nephrology. Clinical, demographical and histological data were collected. Results: A total of 148 patients with cancer who underwent a kidney biopsy from 12 hospitals were included. 64.3% men and mean age of 66.9 years old. The indications for biopsy were acute renal injury (67.1%), proteinuria (17.1%), exacerbated chronic kidney disease (8.2%), and chronic kidney disease (7.5%). Most frequent malignances were lung (29.1%) and abdominal (25%), with 49.7% metastatic cancer. As oncospecific treatment, 28% received chemotherapy, 29.3% immunotherapy, 19.3% specific therapies, and 2.1% conservative treatment. At the time of kidney biopsy, median creatinine was of 2.58 mg/dL [1.81–4.1 (IQ 25–75)], median urine protein-to-creatinine ratio of 700 mg/g [256–2463 (IQ 25–75)] and 53.1% presented hematuria. The most frequent renal biopsy diagnoses were: acute interstitial nephritis (39.9%), acute tubular necrosis (8.8%), IgA nephropathy (7.4%) and membranous nephropathy (6.1%). Median follow-up was 15.2 months [5.7–31.4 (IQ 25–75)]. Conclusions: There is a new trend in kidney disease and cancer patients in terms of diagnosis and treatment. Acute interstitial nephritis has established itself as the most common kidney injury in patients with cancer who underwent a kidney biopsy. Renal biopsy is a valuable tool for diagnosis, treatment, and prognosis of solid organ cancer patients with kidney damage. MDPI 2022-05-21 /pmc/articles/PMC9143132/ /pubmed/35629041 http://dx.doi.org/10.3390/jcm11102915 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bolufer, Mónica
García-Carro, Clara
Blasco, Miquel
Quintana, Luis F.
Shabaka, Amir
Rabasco, Cristina
Draibe, Juliana
Merino, Ana
Melero, María Rosa
Alonso, Fabiola
Buxeda, Anna
Batalha, Paula
Visús, Maria Teresa
Soler, Maria José
Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
title Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
title_full Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
title_fullStr Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
title_full_unstemmed Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
title_short Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
title_sort kidney biopsy in patients with cancer along the last decade: a multicenter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143132/
https://www.ncbi.nlm.nih.gov/pubmed/35629041
http://dx.doi.org/10.3390/jcm11102915
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