Sildenafil-Induced Revascularization of Rat Hindlimb Involves Arteriogenesis through PI3K/AKT and eNOS Activation

Hypoxia and inflammation play a major role in revascularization following ischemia. Sildenafil inhibits phosphodiesterase-5, increases intracellular cGMP and induces revascularization through a pathway which remains incompletely understood. Thus, we investigated the effect of sildenafil on post-isch...

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Detalles Bibliográficos
Autores principales: Baron-Menguy, Celine, Bocquet, Arnaud, Richard, Alexis, Guihot, Anne-Laure, Toutain, Bertrand, Pacaud, Pierre, Fassot, Celine, Loirand, Gervaise, Henrion, Daniel, Loufrani, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143320/
https://www.ncbi.nlm.nih.gov/pubmed/35628350
http://dx.doi.org/10.3390/ijms23105542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143320/
https://www.ncbi.nlm.nih.gov/pubmed/35628350
http://dx.doi.org/10.3390/ijms23105542

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