GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments

Many therapeutic proteins are small in size and are rapidly cleared from circulation. Consequently, half-life extension strategies have emerged to improve pharmacokinetic properties, including fusion or binding to long-lasting serum proteins, chemical modifications with hydrophilic polymers such as...

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Detalles Bibliográficos
Autores principales: Seifert, Oliver, Kontermann, Roland E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143431/
https://www.ncbi.nlm.nih.gov/pubmed/35630749
http://dx.doi.org/10.3390/molecules27103272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143431/
https://www.ncbi.nlm.nih.gov/pubmed/35630749
http://dx.doi.org/10.3390/molecules27103272

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