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A Novel Strategy for Regulating mRNA’s Degradation via Interfering the AUF1’s Binding to mRNA
The study on the mechanism and kinetics of mRNA degradation provides a new vision for chemical intervention on protein expression. The AU enrichment element (ARE) in mRNA 3′-UTR can be recognized and bound by the ARE binding protein (AU-rich Element factor (AUF1) to recruit RNase for degradation. In...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143527/ https://www.ncbi.nlm.nih.gov/pubmed/35630659 http://dx.doi.org/10.3390/molecules27103182 |