Simultaneous Improvement of Dissolution Behavior and Oral Bioavailability of Antifungal Miconazole via Cocrystal and Salt Formation

Miconazole shows low oral bioavailability in humans due to poor aqueous solubility, although it has demonstrated various pharmacological activities such as antifungal, anti-tubercular and anti-tumor effects. Cocrystal/salt formation is one of the effective methods for solving this problem. In this s...

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Detalles Bibliográficos
Autores principales: Drozd, Ksenia V., Manin, Alex N., Boycov, Denis E., Perlovich, German L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143750/
https://www.ncbi.nlm.nih.gov/pubmed/35631693
http://dx.doi.org/10.3390/pharmaceutics14051107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143750/
https://www.ncbi.nlm.nih.gov/pubmed/35631693
http://dx.doi.org/10.3390/pharmaceutics14051107

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