Design and Synthesis of a Novel 4-aryl-N-(2-alkoxythieno [2,3-b]pyrazine-3-yl)-4-arylpiperazine-1-carboxamide DGG200064 Showed Therapeutic Effect on Colon Cancer through G2/M Arrest

Cancer cells are characterized by an abnormal cell cycle. Therefore, the cell cycle has been a potential target for cancer therapeutic agents. We developed a new lead compound, DGG200064 (7c) with a 2-alkoxythieno [2,3-b]pyrazine-3-yl)-4-arylpiperazine-1-carboxamide core skeleton. To evaluate its pr...

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Detalles Bibliográficos
Autores principales: Lee, Eun-Sil, Kim, Nayeon, Kang, Joon Hee, Abdildinova, Aizhan, Lee, Seon-Hyeong, Lee, Myung Hwi, Kang, Nam Sook, Koo, Tae-Sung, Kim, Soo-Youl, Gong, Young-Dae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143821/
https://www.ncbi.nlm.nih.gov/pubmed/35631329
http://dx.doi.org/10.3390/ph15050502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143821/
https://www.ncbi.nlm.nih.gov/pubmed/35631329
http://dx.doi.org/10.3390/ph15050502

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