Phosphorylation at Ser(724) of the ER stress sensor IRE1α governs its activation state and limits ER stress–induced hepatosteatosis

Inositol-requiring enzyme 1 (IRE1) is an evolutionarily conserved sensor of endoplasmic reticulum (ER) stress and mediates a key branch of the unfolded protein response in eukaryotic cells. It is an ER-resident transmembrane protein that possesses Ser/Thr protein kinase and endoribonuclease (RNase)...

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Detalles Bibliográficos
Autores principales: Li, Yang, Huang, Shijia, Wang, Jingsi, Dai, Jianli, Cai, Jie, Yan, Shuai, Huang, Zhiliang, He, Shengqi, Wang, Ping, Liu, Jianmiao, Liu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144033/
https://www.ncbi.nlm.nih.gov/pubmed/35500653
http://dx.doi.org/10.1016/j.jbc.2022.101997

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