Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold

Pyroptosis is a mechanism of inflammatory cell death mediated by the activation of the prolytic protein gasdermin D by caspase-1, caspase-4, and caspase-5 in human, and caspase-1 and caspase-11 in mouse. In addition, caspase-1 amplifies inflammation by proteolytic activation of cytokine interleukin-...

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Detalles Bibliográficos
Autores principales: Bibo-Verdugo, Betsaida, Joglekar, Isha, Karadi Giridhar, Mithun N., Ramirez, Monica L., Snipas, Scott J., Clark, A. Clay, Poreba, Marcin, Salvesen, Guy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article Collection: Immunology (2022)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144055/
https://www.ncbi.nlm.nih.gov/pubmed/35427646
http://dx.doi.org/10.1016/j.jbc.2022.101931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144055/
https://www.ncbi.nlm.nih.gov/pubmed/35427646
http://dx.doi.org/10.1016/j.jbc.2022.101931

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