Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice

Maternal obesity predisposes for hepato-metabolic disorders early in life. However, the underlying mechanisms causing early onset dysfunction of the liver and metabolism remain elusive. Since obesity is associated with subacute chronic inflammation and accelerated aging, we test the hypothesis wheth...

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Detalles Bibliográficos
Autores principales: Kasper, Philipp, Selle, Jaco, Vohlen, Christina, Wilke, Rebecca, Kuiper-Makris, Celien, Klymenko, Oleksiy, Bae-Gartz, Inga, Schömig, Charlotte, Quaas, Alexander, Schumacher, Björn, Demir, Münevver, Bürger, Martin, Lang, Sonja, Martin, Anna, Steffen, Hans-Michael, Goeser, Tobias, Dötsch, Jörg, Alcazar, Miguel A. Alejandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144113/
https://www.ncbi.nlm.nih.gov/pubmed/35628414
http://dx.doi.org/10.3390/ijms23105609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144113/
https://www.ncbi.nlm.nih.gov/pubmed/35628414
http://dx.doi.org/10.3390/ijms23105609

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