The Inhibitors of CDK4/6 from a Library of Marine Compound Database: A Pharmacophore, ADMET, Molecular Docking and Molecular Dynamics Study

Background: CDK4/6 (Cyclin-dependent kinases 4/6) are the key promoters of cell cycle transition from G1 phase to S phase. Thus, selective inhibition of CDK4/6 is a promising cancer treatment. Methods: A total of 52,765 marine natural products were screened for CDK4/6. To screen out better natural c...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Lianxiang, Wang, Qu, Liao, Yinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144134/
https://www.ncbi.nlm.nih.gov/pubmed/35621970
http://dx.doi.org/10.3390/md20050319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144134/
https://www.ncbi.nlm.nih.gov/pubmed/35621970
http://dx.doi.org/10.3390/md20050319

Ejemplares similares