3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer

Chemoresistance limits treatment outcomes in colorectal cancer (CRC) patients. A dimeric metabolite of indole-3-carbinol, 3,3′-diindolylmethane (DIM) is abundant in cruciferous vegetables and has shown anticancer efficacy. The role of DIM in regulating chemosensitivity in CRC remains unknown. In thi...

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Detalles Bibliográficos
Autores principales: Zhang, Jieping, Zou, Shaomin, Zhang, Yijing, Yang, Ziqing, Wang, Wencong, Meng, Manqi, Feng, Junyan, Zhang, Peng, Xiao, Lishi, Lee, Mong-Hong, Fang, Lekun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144298/
https://www.ncbi.nlm.nih.gov/pubmed/35629914
http://dx.doi.org/10.3390/metabo12050410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144298/
https://www.ncbi.nlm.nih.gov/pubmed/35629914
http://dx.doi.org/10.3390/metabo12050410

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