Efficacy of an HSV-1 Neuro-Attenuated Vaccine in Mice Is Reduced by Preventing Viral DNA Replication

We previously isolated an HSV-1 mutant, KOS-NA, that contains two non-synonymous mutations in UL39. One of the mutations, resulting in an R950H amino acid substitution in ICP6, renders KOS-NA severely neuro-attenuated and significantly reduces HSV-1 latency. Vaccination of mice with KOS-NA prior to...

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Detalles Bibliográficos
Autores principales: Wang, Hong, Davido, David J., Mostafa, Heba H., Morrison, Lynda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144315/
https://www.ncbi.nlm.nih.gov/pubmed/35632611
http://dx.doi.org/10.3390/v14050869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144315/
https://www.ncbi.nlm.nih.gov/pubmed/35632611
http://dx.doi.org/10.3390/v14050869

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