The Critical Role of 12-Methyl Group of Anthracycline Dutomycin to Its Antiproliferative Activity

Anthracycline dutomycin is a tetracyclic quinone glycoside produced by Streptomyces minoensis NRRL B-5482. SW91 is a C-12 demethylated dutomycin derivative, which was identified in our previous research. In vitro cytotoxicity and apoptosis assays of these two compounds were conducted to demonstrate...

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Detalles Bibliográficos
Autores principales: Xu, Ruoxuan, Hu, Dinghang, Lin, Jinlian, Tang, Jie, Zhan, Ruoting, Liu, Guiyou, Sun, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144609/
https://www.ncbi.nlm.nih.gov/pubmed/35630823
http://dx.doi.org/10.3390/molecules27103348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144609/
https://www.ncbi.nlm.nih.gov/pubmed/35630823
http://dx.doi.org/10.3390/molecules27103348

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