Fluorine-18 Labeled Urea-Based Ligands Targeting Prostate-Specific Membrane Antigen (PSMA) with Increased Tumor and Decreased Renal Uptake

High expression of prostate-specific membrane antigen (PSMA) in prostate cancers prompted the development of the PSMA-targeted PET-imaging agent [(18)F]DCFPyL, which was recently approved by the FDA. Fluorine-18-labeled Lys–Urea–Glu-based oxime derivatives of [(18)F]DCFPyL were prepared for the comp...

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Detalles Bibliográficos
Autores principales: Basuli, Falguni, Phelps, Tim E., Zhang, Xiang, Woodroofe, Carolyn C., Roy, Jyoti, Choyke, Peter L., Swenson, Rolf E., Jagoda, Elaine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144807/
https://www.ncbi.nlm.nih.gov/pubmed/35631423
http://dx.doi.org/10.3390/ph15050597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144807/
https://www.ncbi.nlm.nih.gov/pubmed/35631423
http://dx.doi.org/10.3390/ph15050597

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