The Anti-Rheumatic Drug, Leflunomide, Induces Nephrotoxicity in Mice via Upregulation of TGFβ-Mediated p53/Smad2/3 Signaling

Recent studies indicated renal toxicity and interstitial nephritis in patients receiving leflunomide (LEFN), but the exact mechanism is still unknown. The transforming growth factor β (TGFβ)/p53/Smad2/3 pathway crucially mediates renal fibrosis. We aimed to assess the nephrotoxic effect of LEFN in m...

Descripción completa

Detalles Bibliográficos
Autores principales: Aljohani, Alhanouf A., Alqarni, Yasmeen S., Alrashidi, Maram N., Aljuhani, Maha H., Shehata, Shaimaa A., El-Kherbetawy, Mohamed K., Prabahar, Kousalya, Alshaman, Reem, Alattar, Abdullah, Helaly, Ahmed M. N., Ateyya, Hayam, Ismail, Ezzat A., Zaitone, Sawsan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144816/
https://www.ncbi.nlm.nih.gov/pubmed/35622687
http://dx.doi.org/10.3390/toxics10050274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144816/
https://www.ncbi.nlm.nih.gov/pubmed/35622687
http://dx.doi.org/10.3390/toxics10050274

Ejemplares similares